For people on Saxenda (liraglutide)
Losing weight on Saxenda? Keep the muscle.
Saxenda takes care of the appetite. Nobody is looking after your muscle. Pooled across 20 randomised trials, 26.8% of the weight people lost on liraglutide was lean mass, and losing the same weight by diet alone cost about as much. The muscle comes off because the weight comes off. This page is the part of the prescription nobody provides.
Saxenda is a daily injection with milder appetite effects than the weekly medications. That makes it easier to eat enough protein, and easier to drift without noticing.

What the trials measured
of weight lost on liraglutide was lean mass in people given the medication and nothing else.
Eisa N et al, Diabetes, Obesity and Metabolism 2026, 20 trials, 15,782 people. Diet alone cost 26.2%.
per kg of goal body weight (0.55 g per lb) is the protein floor. Under it, your body pulls the material from your own muscle.
is the same figure once resistance training is added, the best result of any approach studied. Two 30-minute sessions a week.
On Saxenda specifically
Three things to do in your first month
Set your protein target from your goal weight, not your current weight
Typical Saxenda dosing runs a daily injection, started low and stepped up by your prescriber. Appetite drops before habits change, so most people we hear from are eating 60 to 70 g of protein a day by month two without realising. The floor is 1.2 g per kg of goal weight, or 0.55 g per lb. The calculator does it in ten seconds, in kilos or pounds.
Eat protein first at every meal
On Saxenda you may only manage a few bites before you feel full. If those bites are toast, the protein never arrives. Protein first, then everything else, every time. Injection day and the day after get their own protocol.
Pick one strength test and do it every week
Goblet squats, push-ups, or a 30-second sit-to-stand from a chair. Fat loss does not make you weaker, so a number that drops for three or four weeks in a row is a real signal and it is fixable. It measures what you can do, not how much muscle you have.
The Keep Muscle Kit
Twelve weeks on Saxenda, written down step by step
The workbook, the 2-Day Strength Plan, meal plans at your protein level, the Sunday tracker and the injection-day card. 107 pages, instant download.
A$47 / US$29 / £23 until 6 October. 14-day refund.
Articles for Saxenda users
- Muscle
How to keep your muscle on GLP-1 medication
The mechanism, the numbers and the two things that fix it.
- Side effects
Injection day: exactly what to eat
A nausea-proof protocol for the day of and the day after.
- Plateaus
The plateau that is not a plateau
How to read a 3-month trend before you panic.
Where the figures on this page come from: Eisa N et al, Diabetes, Obesity and Metabolism 2026, 20 randomised controlled trials, 15,782 participants. Every number we state, with its range and how much weight to put on it, is on the evidence page. Last reviewed 18 September 2026.
Nutrition and strength coaching, not medical advice. Saxenda dosing is between you and your prescribing doctor. How we work sets out what we are and are not qualified to tell you, and we are not clinicians.